Ontology highlight
ABSTRACT:
SUBMITTER: Rampa A
PROVIDER: S-EPMC6222323 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Rampa Angela A Bartolini Manuela M Pruccoli Letizia L Naldi Marina M Iriepa Isabel I Moraleda Ignacio I Belluti Federica F Gobbi Silvia S Tarozzi Andrea A Bisi Alessandra A
Molecules (Basel, Switzerland) 20180730 8
Alzheimer's disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper, a series of naturally inspired chalcone-based derivatives were designed as structural simplification of our previously reported benzofuran lead compound, aiming at targeting both acetyl (AChE)- and butyryl (BuChE) cholinesterases that, despite having been studied for years, still deserve considerable attention. In addition, the new compou ...[more]