Ontology highlight
ABSTRACT:
SUBMITTER: Zhou A
PROVIDER: S-EPMC6272137 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20150114 1
Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder characterized by memory loss, language impairment, personality changes and intellectual decline. Taking into account the key pathological features of AD, such as low levels of acetylcholine, beta-amyloid (Aβ) aggregation, oxidative stress and dyshomeostasis of biometals, a new series of paeonol derivatives 5a-5d merging three different functions, i.e., antioxidant, anti-acetylcholinesterase (AChE) activity, metal chelatin ...[more]