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Azukisapogenol Triterpene Glycosides from Oxytropis chiliophylla Royle.

ABSTRACT: Eight azukisapogenol triterpene glycosides, including five new compounds, oxychiliotriterpenosides A?E (1?5), two new methyl glucuronide derivatives that proved to be artifacts, oxychiliotriterpenoside E-glucuronic acid methyl ester (6) and myrioside B-glucuronic acid methyl ester (7), and a known one, myrioside B (8), was isolated from the aerial part of Oxytropis chiliophylla Royle. Their structures were elucidated based on extensive spectroscopic analyses and chemical methods. Triterpene glycosides were first obtained from O. chiliophylla, and those containing a galactose unit (1, 2, 5 and 6) and diglucosidic or triglucosidic linkage at C-29 (1?4), were reported from Oxytropis species for the first time, which might be recognized as a chemotaxonomic feature of O. chiliophylla. All isolated compounds were evaluated for their anti-inflammatory activities against NO production using lipopolysaccharide (LPS)-induced RAW 264.7 cells, but no compounds showed potent inhibition on NO production.

SUBMITTER: Wang J 

PROVIDER: S-EPMC6222378 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Azukisapogenol Triterpene Glycosides from <i>Oxytropis chiliophylla</i> Royle.

Wang Jun J   Yang Hongshuai H   Liu Yang Y   Norbo Kelsang K   Zeng Kewu K   Zhao Mingbo M   Liang Hong H   Tu Pengfei P   Zhang Qingying Q   Zhang Qingying Q  

Molecules (Basel, Switzerland) 20180925 10

Eight azukisapogenol triterpene glycosides, including five new compounds, oxychiliotriterpenosides A⁻E (<b>1</b>⁻<b>5</b>), two new methyl glucuronide derivatives that proved to be artifacts, oxychiliotriterpenoside E-glucuronic acid methyl ester (<b>6</b>) and myrioside B-glucuronic acid methyl ester (<b>7</b>), and a known one, myrioside B (<b>8</b>), was isolated from the aerial part of <i>Oxytropis chiliophylla</i> Royle. Their structures were elucidated based on extensive spectroscopic anal  ...[more]

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