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Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their ?-Glucosidase Inhibitory Activities.

ABSTRACT: Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against ?-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 ?M comparing with the positive control (acarbose, IC₅₀ 87.65?±?6.51 ?M).

SUBMITTER: Gao Y

PROVIDER: S-EPMC7253571 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities.

Gao Ya Y Chen Jian-Chao JC Peng Xing-Rong XR Li Zhong-Rong ZR Su Hai-Guo HG Qiu Ming-Hua MH

Natural products and bioprospecting 20200506 3

Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their 13C NMR data with liter ...[more]

PMID: 32378043

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