Ontology highlight
ABSTRACT:
SUBMITTER: Vincek AS
PROVIDER: S-EPMC6222455 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Vincek Adam S AS Patel Jigneshkumar J Jaganathan Anbalagan A Green Antonia A Pierre-Louis Valerie V Arora Vimal V Rehmann Jill J Mezei Mihaly M Zhou Ming-Ming MM Ohlmeyer Michael M Mujtaba Shiraz S
Molecules (Basel, Switzerland) 20180802 8
Tumor suppressor p53-directed apoptosis triggers loss of normal cells, which contributes to the side-effects from anticancer therapies. Thus, small molecules with potential to downregulate the activation of p53 could minimize pathology emerging from anticancer therapies. Acetylation of p53 by the histone acetyltransferase (HAT) domain is the hallmark of coactivator CREB-binding protein (CBP) epigenetic function. During genotoxic stress, CBP HAT-mediated acetylation is essential for the activatio ...[more]