Ontology highlight
ABSTRACT:
SUBMITTER: Nieto CI
PROVIDER: S-EPMC6222706 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nieto Carla I CI Cornago María Pilar MP Cabildo María Pilar MP Sanz Dionisia D Claramunt Rosa M RM Torralba María Carmen MC Torres María Rosario MR Martínez Casanova Diana D Sánchez-Alegre Yaiza Rebeca YR Escudero Esther E Lavandera José Luis JL
Molecules (Basel, Switzerland) 20180724 8
A series of fourteen new asymmetrical 1,3-diketone derivatives have been synthesized and evaluated in the ABTS, FRAP and DPPH assays as a new chemotype with antioxidant and drug-like properties. All the compounds displayed low cytotoxicity in comparison to curcumin against the human neuroblastoma SH-SY5Y cell line. Among them, (3<i>Z</i>,5<i>E</i>)-6-(2,5-difluoro-4-hydroxy-phenyl)-1,1,1-trifluoro-4-hydroxyhexa-3,5-dien-2-one (<b>6b</b>) and (3<i>Z</i>,5<i>E</i>)-6-(2,3-difluoro-4-hydroxy-phenyl ...[more]