Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration† † Electronic supplementary information (ESI) available: Experimental procedures, full spectroscopic data for new compounds, and crystallographic data for 2j and 5g. CCDC 1959877 and 1959878. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc06309a

ABSTRACT: The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition–cyclization reactions is an alkenyl-to-aryl 1,4-Rh(i) migration, which enables arylboronic acids to function effectively as 1,2-dimetalloarene surrogates. The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with alkynyl 1,3-diketones is described. The key step in these reactions is an alkenyl-to-aryl 1,4-Rh(i) migration..

SUBMITTER: Groves A 

PROVIDER: S-EPMC8157494 | biostudies-literature |

REPOSITORIES: biostudies-literature