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Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media.

ABSTRACT: A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K?CO?, EtOH/H?O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The methodology allows the facile production of heterobiaryl compounds, a unique architectural motif that is ubiquitous in medicinal chemistry.

SUBMITTER: Chen Q

PROVIDER: S-EPMC6222736 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Synthesis of New 2-Arylbenzo[<i>b</i>]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media.

Chen Qianqian Q Jiang Panli P Guo Mengping M Yang Jianxin J

Molecules (Basel, Switzerland) 20180925 10

A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K₂CO₃, EtOH/H₂O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The methodology allows the facile production of heterobiaryl compounds, a unique architectural motif that is ubiquitous in medicinal chemistry. ...[more]

PMID: 30257438

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