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A Dynamic Overview of Antimicrobial Peptides and Their Complexes.

ABSTRACT: In this narrative review, we comprehensively review the available information about the recognition, structure, and dynamics of antimicrobial peptides (AMPs). Their complex behaviors occur across a wide range of time scales and have been challenging to portray. Recent advances in nuclear magnetic resonance and molecular dynamics simulations have revealed the importance of the molecular plasticity of AMPs and their abilities to recognize targets. We also highlight experimental data obtained using nuclear magnetic resonance methodologies, showing that conformational selection is a major mechanism of target interaction in AMP families.

SUBMITTER: de Paula VS

PROVIDER: S-EPMC6222744 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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A Dynamic Overview of Antimicrobial Peptides and Their Complexes.

de Paula Viviane Silva VS Valente Ana Paula AP

Molecules (Basel, Switzerland) 20180815 8

In this narrative review, we comprehensively review the available information about the recognition, structure, and dynamics of antimicrobial peptides (AMPs). Their complex behaviors occur across a wide range of time scales and have been challenging to portray. Recent advances in nuclear magnetic resonance and molecular dynamics simulations have revealed the importance of the molecular plasticity of AMPs and their abilities to recognize targets. We also highlight experimental data obtained using ...[more]

PMID: 30111717

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