Dataset Information

Surgical outcome after standard abdominoperineal resection: A 15-year cohort study from a single cancer centre.

ABSTRACT:

Background

Abdominoperineal resection (APR) is associated with a poorer oncological outcome than anterior resection. This may be due to higher rates of intra-operative perforation and circumferential resection margin involvement. The aim of this study was to audit our short and long-term results of abdominoperineal resection performed using conventional techniques and to compare this with other published series.

Materials and methods

A retrospective review of all patients who had standard APR between January 2000 and December 2016 in a single institution, Cabrini Hospital, Melbourne, Australia. A total of 163 cases performed by nine different colorectal surgeons for primary rectal adenocarcinoma were identified, with their clinicopathological data analysed.

Results

Using standard APR, only six patients (3.7%) were found to have a positive circumferential resection margin (CRM). There were two cases of intra-operative perforation (1.2%). Local recurrence rate was 5.6% of patients, with distant recurrence found in 24.9%. Disease-free survival at five years was 73.1%. Five-year overall survival was 66.7%, 67.9% of all deaths were cancer-related.

Conclusion

Short and long-term outcomes after standard APR in this study were comparable to previous published studies. The CRM rate of 3.7% compares favourably to published positive CRM rates for standard APR which ranged from 6 to 18%. Standard APR remains a viable technique for the treatment of rectal cancer. Patient selection and adequate training remain important factors.

SUBMITTER: Wilkins S

PROVIDER: S-EPMC6224354 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Surgical outcome after standard abdominoperineal resection: A 15-year cohort study from a single cancer centre.

Wilkins S S Yap R R Loon K K Staples M M Oliva K K Ruggiero B B McMurrick P P Carne P P

Annals of medicine and surgery (2012) 20181031

<h4>Background</h4>Abdominoperineal resection (APR) is associated with a poorer oncological outcome than anterior resection. This may be due to higher rates of intra-operative perforation and circumferential resection margin involvement. The aim of this study was to audit our short and long-term results of abdominoperineal resection performed using conventional techniques and to compare this with other published series.<h4>Materials and methods</h4>A retrospective review of all patients who had ...[more]

PMID: 30425830

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Dataset Information

Surgical outcome after standard abdominoperineal resection: A 15-year cohort study from a single cancer centre.

Background

Materials and methods

Results

Conclusion

Publications

Surgical outcome after standard abdominoperineal resection: A 15-year cohort study from a single cancer centre.

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