Ontology highlight
ABSTRACT:
SUBMITTER: Yan M
PROVIDER: S-EPMC6224598 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell death & disease 20181108 11
Epithelial ovarian carcinoma (EOC) is the most lethal gynecologic malignancy. However, the molecular mechanisms remain unclear. In this study, we found that miR-146b was downregulated in EOC and its expression level was negatively correlated with the pathological staging. Follow-up functional experiments illustrated that overexpression of miR-146b significantly inhibited cell migration and invasion, and increased cell proliferation, but it also improved the response to chemotherapeutic agents. M ...[more]