Ontology highlight
ABSTRACT:
SUBMITTER: Sansook S
PROVIDER: S-EPMC6225114 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Sansook Supojjanee S Lineham Ella E Hassell-Hart Storm S Tizzard Graham J GJ Coles Simon J SJ Spencer John J Morley Simon J SJ
Molecules (Basel, Switzerland) 20180823 9
Two novel ferrocene-containing compounds based upon a known MNK1/2 kinase (MAPK-interacting kinase) inhibitor have been synthesized. The compounds were designed to use the unique shape of ferrocene to exploit a large hydrophobic pocket in MNK1/2 that is only partially occupied by the original compound. Screening of the ferrocene analogues showed that both exhibited potent anticancer effects in several breast cancer and AML (acute myeloid leukemia) cell lines, despite a loss of MNK potency. The m ...[more]