Dataset Information

The ?-Cyclodextrin/Moringin Complex: A New Promising Antimicrobial Agent against Staphylococcus aureus.

ABSTRACT: Antimicrobial resistance is one of the major clinical concerns, making the discovery of new antimicrobial drugs desirable. Moringin (MOR), the major isothiocyanate produced from Moringa oleifera seeds, could represent an alternative therapeutic strategy to commonly used antibiotics. The aim of our study was to investigate the antimicrobial effect of MOR conjugated with ?-cyclodextrin (MOR/?-CD), a complex with an improved solubility and stability in aqueous solutions. Our data demonstrated that MOR/?-CD was able to exert antimicrobial activity against the S. aureus reference strains (ATCC 25923, ATCC 6538, and ATCC BAA-977). Moreover, MOR/?-CD showed bacteriostatic effects (MIC = minimum inhibitory concentration = 0.5 mg/mL) and bactericidal properties (MBC = minimum bactericidal concentration = 1 mg/mL) against the overall assessed strains. In addition, MOR/?-CD showed bactericidal activity against the S. aureus strain ATCC BAA-977 after treatment with erythromycin (Ery), which induced clindamycin-resistance on the erm (A) gene. This evidence led us to assume that MOR/?-CD could be a promising antimicrobial agent against strains with the clindamycin-resistant phenotype (CC-resistant).

SUBMITTER: Romeo L

PROVIDER: S-EPMC6225138 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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The α-Cyclodextrin/Moringin Complex: A New Promising Antimicrobial Agent against <i>Staphylococcus aureus</i>.

Romeo Letizia L Lanza Cariccio Veronica V Iori Renato R Rollin Patrick P Bramanti Placido P Mazzon Emanuela E

Molecules (Basel, Switzerland) 20180821 9

Antimicrobial resistance is one of the major clinical concerns, making the discovery of new antimicrobial drugs desirable. Moringin (MOR), the major isothiocyanate produced from <i>Moringa oleifera</i> seeds, could represent an alternative therapeutic strategy to commonly used antibiotics. The aim of our study was to investigate the antimicrobial effect of MOR conjugated with α-cyclodextrin (MOR/α-CD), a complex with an improved solubility and stability in aqueous solutions. Our data demonstrate ...[more]

PMID: 30134562

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Project description:BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) has been responsible for serious hospital infections worldwide. Nanomaterials are an alternative to conventional antibiotic compounds, because bacteria are unlikely to develop microbial resistance against nanomaterials. In the past decade, graphene oxide (GO) has emerged as a material that is often used to support and stabilize silver nanoparticles (AgNPs) for the preparation of novel antibacterial nanocomposites. In this work, we report the synthesis of the graphene-oxide silver nanocomposite (GO-Ag) and its antibacterial activity against relevant microorganisms in medicine.Materials and methodsGO-Ag nanocomposite was synthesized through the reduction of silver ions (Ag(+)) by sodium citrate in an aqueous GO dispersion, and was extensively characterized using ultraviolet-visible absorption spectroscopy, X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, and transmission electron microscopy. The antibacterial activity was evaluated by microdilution assays and time-kill experiments. The morphology of bacterial cells treated with GO-Ag was investigated via transmission electron microscopy.ResultsAgNPs were well distributed throughout GO sheets, with an average size of 9.4±2.8 nm. The GO-Ag nanocomposite exhibited an excellent antibacterial activity against methicillin-resistant S. aureus, Acinetobacter baumannii, Enterococcus faecalis, and Escherichia coli. All (100%) MRSA cells were inactivated after 4 hours of exposure to GO-Ag sheets. In addition, no toxicity was found for either pristine GO or bare AgNPs within the tested concentration range. Transmission electronic microscopy images offered insights into how GO-Ag nanosheets interacted with bacterial cells.ConclusionOur results indicate that the GO-Ag nanocomposite is a promising antibacterial agent against common nosocomial bacteria, particularly antibiotic-resistant MRSA. Morphological injuries on MRSA cells revealed a likely loss of viability as a result of the direct contact between bacteria and the GO-Ag sheets.

Dataset Information

The ?-Cyclodextrin/Moringin Complex: A New Promising Antimicrobial Agent against Staphylococcus aureus.

Publications

The α-Cyclodextrin/Moringin Complex: A New Promising Antimicrobial Agent against <i>Staphylococcus aureus</i>.

Similar Datasets

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