Ionic Liquids: Efficient Media for the Lipase-Catalyzed Michael Addition.

ABSTRACT: Recently, ionic liquids (ILs) have been regarded as ideal media for non-aqueous bio-catalysis. In this work, the synthesis of warfarin by the lipase-catalyzed Michael addition in IL media and the parameters that affected the warfarin yield were investigated. Experimental results demonstrated that the chemical structures of the ILs were a major factor for influencing the warfarin yield. The ILs containing the NTf₂^⁻ anion were suitable reaction media due to the high chemical stability of this anion. The incorporation of the hydroxyl group on the IL cation significantly improved the lipase activity due to the H₂O-mimicking property of this group. The lipase activity decreased by increasing the alkyl chain length on the IL cation due to the non-polar domain formation of the IL catio

SUBMITTER: Fan Y 

PROVIDER: S-EPMC6225191 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature