Unknown

Dataset Information

0

Iodide/H?O? Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles.


ABSTRACT: An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2'-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant.

SUBMITTER: Gao YT 

PROVIDER: S-EPMC6225319 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Iodide/H₂O₂ Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles.

Gao Yu-Ting YT   Jin Xiao-Yang XY   Liu Qi Q   Liu An-Di AD   Cheng Liang L   Wang Dong D   Liu Li L  

Molecules (Basel, Switzerland) 20180905 9


An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2'-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant. ...[more]

Similar Datasets

| S-EPMC3298079 | biostudies-literature
| S-EPMC9089239 | biostudies-literature
| S-EPMC4038966 | biostudies-literature
| S-EPMC3087841 | biostudies-literature
| S-EPMC3429346 | biostudies-literature
| S-EPMC6641745 | biostudies-literature
| S-EPMC3314298 | biostudies-literature
| S-EPMC7948442 | biostudies-literature
| S-EPMC5238593 | biostudies-literature
| S-EPMC8159277 | biostudies-literature