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Iodide/H?O? Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles.

ABSTRACT: An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2'-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant.

SUBMITTER: Gao YT

PROVIDER: S-EPMC6225319 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Iodide/H₂O₂ Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles.

Gao Yu-Ting YT Jin Xiao-Yang XY Liu Qi Q Liu An-Di AD Cheng Liang L Wang Dong D Liu Li L

Molecules (Basel, Switzerland) 20180905 9

An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2'-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant. ...[more]

PMID: 30189635

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