Ontology highlight
ABSTRACT:
SUBMITTER: Sangpheak K
PROVIDER: S-EPMC6225485 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sangpheak Kanyani K Mueller Monika M Darai Nitchakan N Wolschann Peter P Suwattanasophon Chonticha C Ruga Ritbey R Chavasiri Warinthon W Seetaha Supaporn S Choowongkomon Kiattawee K Kungwan Nawee N Rungnim Chompoonut C Rungrotmongkol Thanyada T
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Targeted cancer therapy has become one of the high potential cancer treatments. Human topoisomerase II (hTopoII), which catalyzes the cleavage and rejoining of double-stranded DNA, is an important molecular target for the development of novel cancer therapeutics. In order to diversify the pharmacological activity of chalcones and to extend the scaffold of topoisomerase inhibitors, a series of chalcones was screened against hTopoIIα by computational techniques, and subsequently tested for their i ...[more]