Ontology highlight
ABSTRACT:
SUBMITTER: Sankara Rao N
PROVIDER: S-EPMC6350626 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sankara Rao N N Nagesh Narayana N Lakshma Nayak V V Sunkari Satish S Tokala Ramya R Kiranmai Gaddam G Regur Phanindranath P Shankaraiah Nagula N Kamal Ahmed A
MedChemComm 20181108 1
A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their <i>in vitro</i> cytotoxicity on selected human cancer cell lines. Among them, derivatives <b>4a</b> and <b>4b</b> with the 6-aminobenzothiazole ring and <b>5g</b> with the cinnamide ring displayed potent cytotoxic activity against colon (IC<sub>50</sub>: 3.715 and 3.467 μM) and lung cancer (IC<sub>50</sub>: 4.074 and 3.890 μM) cell lines when compared to amonafide (IC<sub>5 ...[more]