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Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study.


ABSTRACT: OBJECTIVES:Implicit regulation of emotions involves medial-prefrontal cortex (mPFC) regions exerting regulatory control over limbic structures. Diminished regulation relates to aberrant mPFC functionality and psychopathology. Establishing means of modulating mPFC functionality could benefit research on emotion and its dysregulation. Here, we tested the capacity of transcranial direct current stimulation (tDCS) targeting mPFC to modulate subjective emotional states by facilitating implicit emotion regulation. MATERIALS AND METHODS:Stimulation was applied concurrently with functional magnetic resonance imaging to validate its neurobehavioral effect. Sixteen participants were each scanned twice, counterbalancing active and sham tDCS application, while undergoing negative mood induction (clips featuring negative vs. neutral contents). Effects of stimulation on emotional experience were assessed using subjective and neural measures. RESULTS:Subjectively, active stimulation led to significant reduction in reported intensity of experienced emotions to negatively valenced (p?=?0.005) clips but not to neutral clips (p?>?0.99). Active stimulation further mitigated a rise in stress levels from pre- to post-induction (sham: p?=?0.004; active: p?=?0.15). Neurally, stimulation increased activation in mPFC regions associated with implicit emotion regulation (ventromedial-prefrontal cortex; subgenual anterior-cingulate cortex, sgACC), and in ventral striatum, a core limbic structure (all ps??0.64, ps?

SUBMITTER: Abend R 

PROVIDER: S-EPMC6226375 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study.

Abend Rany R   Sar-El Roy R   Gonen Tal T   Jalon Itamar I   Vaisvaser Sharon S   Bar-Haim Yair Y   Hendler Talma T  

Neuromodulation : journal of the International Neuromodulation Society 20180509 8


<h4>Objectives</h4>Implicit regulation of emotions involves medial-prefrontal cortex (mPFC) regions exerting regulatory control over limbic structures. Diminished regulation relates to aberrant mPFC functionality and psychopathology. Establishing means of modulating mPFC functionality could benefit research on emotion and its dysregulation. Here, we tested the capacity of transcranial direct current stimulation (tDCS) targeting mPFC to modulate subjective emotional states by facilitating implici  ...[more]

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