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Protein phosphatases in chromatin structure and function.

ABSTRACT: Chromatin structure and dynamics are highly controlled and regulated processes that play an essential role in many aspects of cell biology. The chromatin transition stages and the factors that control this process are regulated by post-translation modifications, including phosphorylation. While the role of protein kinases in chromatin dynamics has been quite well studied, the nature and regulation of the counteracting phosphatases represent an emerging field but are still at their infancy. In this review we summarize the current literature on phosphatases involved in the regulation of chromatin structure and dynamics, with emphases on the major knowledge gaps that should require attention and more investigation.

SUBMITTER: Gil RS

PROVIDER: S-EPMC6227384 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Protein phosphatases in chromatin structure and function.

Gil Raquel Sales RS Vagnarelli Paola P

Biochimica et biophysica acta. Molecular cell research 20180720 1

Chromatin structure and dynamics are highly controlled and regulated processes that play an essential role in many aspects of cell biology. The chromatin transition stages and the factors that control this process are regulated by post-translation modifications, including phosphorylation. While the role of protein kinases in chromatin dynamics has been quite well studied, the nature and regulation of the counteracting phosphatases represent an emerging field but are still at their infancy. In th ...[more]

PMID: 30036566

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