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Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells.

ABSTRACT: Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of ?-cells. Using a transgenic zebrafish, we screened ~50 seaweed crude extracts to identify materials that protect ?-cells from free fatty acid damage. We found that an extract of the red seaweed Polysiphonia japonica (PJE) had a ?-cell protective effect. We examined the protective effect of PJE on palmitate-induced damage in ?-cells. PJE was found to preserve cell viability and glucose-induced insulin secretion in a pancreatic ?-cell line, Ins-1, treated with palmitate. Additionally, PJE prevented palmitate-induced insulin secretion dysfunction in zebrafish embryos and mouse primary islets and improved insulin secretion in ?-cells against palmitate treatment. These findings suggest that PJE protects pancreatic ?-cells from palmitate-induced damage. PJE may be a potential therapeutic functional food for diabetes.

SUBMITTER: Cha SH 

PROVIDER: S-EPMC6230388 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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<i>Polysiphonia japonica</i> Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells.

Cha Seon-Heui SH   Kim Hyun-Soo HS   Hwang Yongha Y   Jeon You-Jin YJ   Jun Hee-Sook HS  

Oxidative medicine and cellular longevity 20181028

Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of <i>β</i>-cells. Using a transgenic zebrafish, we screened ~50 seaweed crude extracts to identify materials that protect <i>β</i>-cells from free fatty acid damage. We found that an extract of the red seaweed <i>Polysiphonia japonica</i> (PJE) had a <i>β</i>-cell protective effect. We examined the protective effect of PJE on palmitate-induced damage in <i>β</i>-cells.  ...[more]

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