Ontology highlight
ABSTRACT:
SUBMITTER: Brooks AF
PROVIDER: S-EPMC6231179 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Brooks Allen F AF Drake Lindsey R LR Shao Xia X Zhao Austin A Scott Peter J H PJH Kilbourn Michael R MR
ACS medicinal chemistry letters 20181003 11
The development of a positron emission tomography (PET)/magnetic resonance spectroscopy (MRS) hybrid imaging agent allows for functional imaging by both methods with a single imaging agent. Enzyme substrates that are cleaved to form two metabolites present an interesting opportunity, as the unique metabolites generated might each be detected by a different modality. To be successful, such enzyme substrates would require administration of doses that (a) reach the <i>in vivo</i> target tissue at c ...[more]