Ontology highlight
ABSTRACT:
SUBMITTER: Lai TH
PROVIDER: S-EPMC7956753 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20210225 5
The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound (<b>PPY</b>). Among those, the highly affine 4-fluorobenzyl derivate (<b>PPY1</b>; <i>K</i><sub>i</sub ...[more]