Ontology highlight
ABSTRACT:
SUBMITTER: Akagi K
PROVIDER: S-EPMC6233930 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Akagi Kazutaka K Wilson Kenneth A KA Katewa Subhash D SD Ortega Mauricio M Simons Jesse J Hilsabeck Tyler A TA Kapuria Subir S Sharma Amit A Jasper Heinrich H Kapahi Pankaj P
PLoS genetics 20181101 11
Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the age-related decline in intestinal integrity by enhancing enterocyte cellular fitness through up-regulation of dMyc in the intestinal epithelium. Reduction of dMyc in enterocytes induced cell death, which leads to increased gut permeabilit ...[more]