Ontology highlight
ABSTRACT:
SUBMITTER: Luis NM
PROVIDER: S-EPMC5089850 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Luis Nuno Miguel NM Wang Lifen L Ortega Mauricio M Deng Hansong H Katewa Subhash D SD Li Patrick Wai-Lun PW Karpac Jason J Jasper Heinrich H Kapahi Pankaj P
Cell reports 20161001 5
Dietary restriction (DR) is one of the most robust lifespan-extending interventions in animals. The beneficial effects of DR involve a metabolic adaptation toward increased triglyceride usage. The regulatory mechanism and the tissue specificity of this metabolic switch remain unclear. Here, we show that the IRE1/XBP1 endoplasmic reticulum (ER) stress signaling module mediates metabolic adaptation upon DR in flies by promoting triglyceride synthesis and accumulation in enterocytes (ECs) of the Dr ...[more]