Ontology highlight
ABSTRACT:
SUBMITTER: Woodruff MC
PROVIDER: S-EPMC6235168 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Woodruff Matthew Charles MC Kim Eui Ho EH Luo Wei W Pulendran Bali B
Cell reports 20181001 2
The immune system responds preferentially to particular antigenic-epitopes contained within complex immunogens, such as proteins or microbes. This poorly understood phenomenon, termed "immunodominance," remains an obstacle to achieving polyvalent immune responses against multiple antigenic-epitopes through vaccination. We observed profound suppression in the hapten-specific antibody response in mice immunized with hapten-protein conjugate, mixed with an excess of protein, relative to that in mic ...[more]