Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model.

ABSTRACT: Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium. We demonstrate that coordinated excitatory synaptic inputs evoke enhanced calcium elevation specific to stimulated spines, with lower but physiologically relevant calcium elevation in nearby non-stimulated spines. Results further show a novel and important function of inhibition-to enhance the differe

SUBMITTER: Dorman DB 

PROVIDER: S-EPMC6235562 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature