Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
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ABSTRACT:
SUBMITTER: Sud A
PROVIDER: S-EPMC6236462 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Sud Amit A Thomsen Hauke H Orlando Giulia G Försti Asta A Law Philip J PJ Broderick Peter P Cooke Rosie R Hariri Fadi F Pastinen Tomi T Easton Douglas F DF Pharoah Paul D P PDP Dunning Alison M AM Peto Julian J Canzian Federico F Eeles Rosalind R Kote-Jarai ZSofia Z Muir Kenneth K Pashayan Nora N Campa Daniele D Hoffmann Per P Nöthen Markus M MM Jöckel Karl-Heinz KH von Strandmann Elke Pogge EP Swerdlow Anthony J AJ Engert Andreas A Orr Nick N Orr Nick N Hemminki Kari K Houlston Richard S RS
Blood 20180907 19
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; <i>P</i> = 2.11 × 10<sup>-10</sup>), 6q23.3 (rs1002658; <i>P</i> = 2.97 × 10<sup>-8</sup>), 11q23.1 (rs7111520; <i>P</i> = 1.44 × 10<sup>-11</sup>), 16p11.2 (rs6565176; <i>P</i> = 4.00 × 10<sup>-8</sup>), and 20q13.12 (rs2425752; <i>P</i> = 2.01 ...[more]
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