Gluconeogenesis and risk for fasting hyperglycemia in Black and White women.
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ABSTRACT:
SUBMITTER: Chung ST
PROVIDER: S-EPMC6237227 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Gluconeogenesis and risk for fasting hyperglycemia in Black and White women.
Chung Stephanie T ST Courville Amber B AB Onuzuruike Anthony U AU Galvan-De La Cruz Mirella M Mabundo Lilian S LS DuBose Christopher W CW Kasturi Kannan K Cai Hongyi H Gharib Ahmed M AM Walter Peter J PJ Garraffo H Martin HM Chacko Shaji S Haymond Morey W MW Sumner Anne E AE
JCI insight 20180920 18
Black women, compared with White women, have high rates of whole-body insulin resistance but a lower prevalence of fasting hyperglycemia and hepatic steatosis. This dissociation of whole-body insulin resistance from fasting hyperglycemia may be explained by racial differences in gluconeogenesis, hepatic fat, or tissue-specific insulin sensitivity. Two groups of premenopausal federally employed women, without diabetes were studied. Using stable isotope tracers, [2H2O] and [6,62-H2]glucose, basal ...[more]
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