Ontology highlight
ABSTRACT:
SUBMITTER: Charnaud SC
PROVIDER: S-EPMC6237293 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Charnaud Sarah C SC Kumarasingha Rasika R Bullen Hayley E HE Crabb Brendan S BS Gilson Paul R PR
PloS one 20181115 11
Malaria parasites remodel their host erythrocytes to gain nutrients and avoid the immune system. Host erythrocytes are modified by hundreds of effector proteins exported from the parasite into the host cell. Protein export is mediated by the PTEX translocon comprising five core components of which EXP2 is considered to form the putative pore that spans the vacuole membrane enveloping the parasite within its erythrocyte. To explore the function and importance of EXP2 for parasite survival in the ...[more]