Ontology highlight
ABSTRACT:
SUBMITTER: Caron M
PROVIDER: S-EPMC6237371 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Caron Maxime M St-Onge Pascal P Drouin Simon S Richer Chantal C Sontag Thomas T Busche Stephan S Bourque Guillaume G Pastinen Tomi T Sinnett Daniel D
PloS one 20181115 11
Very long intergenic non-coding RNAs (vlincRNAs) are a novel class of long transcripts (~50 kb to 1 Mb) with cell type- or cancer-specific expression. We report the discovery and characterization of 256 vlincRNAs from a cohort of 64 primary childhood pre-B and pre-T acute lymphoblastic leukemia (cALL) samples, of which 61% are novel and specifically expressed in cALL. Validation was performed in 35 pre-B and pre-T cALL primary samples. We show that their expression is cALL immunophenotype and mo ...[more]