Ontology highlight
ABSTRACT:
SUBMITTER: Borst AJ
PROVIDER: S-EPMC6237438 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
eLife 20181107
VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4<sub>BS</sub>) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). Unlike mature antibodies, corresponding VRC01 germline precursors poorly bind to Env. Immunogen design has mostly relied on glycan removal from trimeric Env constructs and has had limited success in eliciting mature VRC01 bnAbs. To better understand elicitation of such bnAbs, we characterized the inferred germline precursor of VRC ...[more]