Ontology highlight
ABSTRACT:
SUBMITTER: Schuliga M
PROVIDER: S-EPMC6237609 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Schuliga Michael M Pechkovsky Dmitri V DV Read Jane J Waters David W DW Blokland Kaj E C KEC Reid Andrew T AT Hogaboam Cory M CM Khalil Nasreen N Burgess Janette K JK Prêle Cecilia M CM Mutsaers Steven E SE Jaffar Jade J Westall Glen G Grainge Christopher C Knight Darryl A DA
Journal of cellular and molecular medicine 20180926 12
Increasing evidence highlights that senescence plays an important role in idiopathic pulmonary fibrosis (IPF). This study delineates the specific contribution of mitochondria and the superoxide they form to the senescent phenotype of lung fibroblasts from IPF patients (IPF-LFs). Primary cultures of IPF-LFs exhibited an intensified DNA damage response (DDR) and were more senescent than age-matched fibroblasts from control donors (Ctrl-LFs). Furthermore, IPF-LFs exhibited mitochondrial dysfunction ...[more]