Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC6237815 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yang Chun C Wu Ruiqi R Liu Hehua H Chen Yiqing Y Gao Yanqing Y Chen Xi X Li Yangyang Y Ma Jinbiao J Li Jixi J Gan Jianhua J
Nucleic acids research 20181101 20
Mitochondrial nucleases play important roles in accurate maintenance and correct metabolism of mtDNA, the own genetic materials of mitochondria that are passed exclusively from mother to child. MGME1 is a highly conserved DNase that was discovered recently. Mutations in MGME1-coding gene lead to severe mitochondrial syndromes characterized by external ophthalmoplegia, emaciation, and respiratory failure in humans. Unlike many other nucleases that are distributed in multiple cellular organelles, ...[more]