Ontology highlight
ABSTRACT:
SUBMITTER: Veenstra VL
PROVIDER: S-EPMC6237826 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Veenstra V L VL Damhofer H H Waasdorp C C van Rijssen L B LB van de Vijver M J MJ Dijk F F Wilmink H W HW Besselink M G MG Busch O R OR Chang D K DK Bailey P J PJ Biankin A V AV Kocher H M HM Medema J P JP Li J S JS Jiang R R Pierce D W DW van Laarhoven H W M HWM Bijlsma M F MF
Oncogenesis 20181116 11
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma that harbors tumor-promoting properties. No good biomarkers exist to monitor the effect of stromal targeting therapies or to predict response. We set out to identify such non-invasive markers for PDAC stroma and predict response to therapy. Gene expression datasets, co-culture experiments, xenografts, and patient samples were analyzed. Serum samples were measured from a cohort of 58 resected patients, and 87 metastatic o ...[more]