Ontology highlight
ABSTRACT:
SUBMITTER: Lobach I
PROVIDER: S-EPMC6239944 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Genetic epidemiology 20181009 8
Genetic studies are continuing to generate volumes and variety of data that can be used to examine the genetic effects. Often the effect of a genetic variant varies by nongenetic measures, what is traditionally defined as gene-environment interaction (G×E). If the G×E term is neglected, estimates of the main effects can be substantially biased. We derive a general and convenient approximation to the magnitude of bias in the estimates due to omitting the G×E term. We show that the approximation i ...[more]