Ontology highlight
ABSTRACT:
SUBMITTER: Lobach I
PROVIDER: S-EPMC6416064 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lobach Iryna I Sampson Joshua J Lobach Siarhei S Alekseyenko Alexander A Piryatinska Alexandra A He Tao T Zhang Li L
Genetic epidemiology 20190108 3
One of the most important research areas in case-control Genome-Wide Association Studies is to determine how the effect of a genotype varies across the environment or to measure the gene-environment interaction (G × E). We consider the scenario when some of the "healthy" controls actually have the disease and when the frequency of these latent cases varies by the environmental variable of interest. In this scenario, performing logistic regression with the clinically diagnosed disease status as a ...[more]