Ontology highlight
ABSTRACT:
SUBMITTER: Pilkington EH
PROVIDER: S-EPMC6239983 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Pilkington Emily H EH Gustafsson Ove J R OJR Xing Yanting Y Hernandez-Fernaud Juan J Zampronio Cleidi C Kakinen Aleksandr A Faridi Ava A Ding Feng F Wilson Paul P Ke Pu Chun PC Davis Thomas P TP
ACS nano 20180516 6
Amyloids may be regarded as native nanomaterials that form in the presence of complex protein mixtures. By drawing an analogy with the physicochemical properties of nanoparticles in biological fluids, we hypothesized that amyloids should form a protein corona in vivo that would imbue the underlying amyloid with a modified biological identity. To explore this hypothesis, we characterized the protein corona of human islet amyloid polypeptide (IAPP) fibrils in fetal bovine serum using two complemen ...[more]