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Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study.

ABSTRACT: BACKGROUND:Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. METHODS:In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. RESULTS:Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. CONCLUSIONS:Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.

SUBMITTER: Haapanen MJ

PROVIDER: S-EPMC6240457 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study.

Haapanen M J MJ Perälä M M MM Osmond C C Salonen M K MK Kajantie E E Rantanen T T Simonen M M Pohjolainen P P Eriksson J G JG von Bonsdorff M B MB

Aging clinical and experimental research 20180724 5

<h4>Background</h4>Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.<h4>Methods</h4>In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.<h4>Results</h4>Greater BMI gain between 2 and 11 years in boys was associated with ...[more]

PMID: 30043315

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Prenatal and childhood growth and physical performance in old age--findings from the Helsinki Birth Cohort Study 1934-1944.

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Birthweight, childhood growth and left ventricular structure at age 60-64 years in a British birth cohort study.

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| S-EPMC5841632 | biostudies-literature

Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study.

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| S-EPMC6150438 | biostudies-literature

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