Dataset Information

Peritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients.

ABSTRACT:

Background

Cancer cachexia (CC) is a multifactorial syndrome, often irreversible, that affects patients with cancer influenced, in part, by the inflammatory condition. Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, and growth factors; given the possible crosstalk between the peritumoural adipose tissue and tumour, these may play an important role in cancer biology and carcinogenesis.

Methods

The aim of this study was to evaluate the factors produced by peritumoural adipose tissue in a cohort of 16 colorectal cancer patients with either weight-stable cancer (WSC; n = 7) or CC (n = 9). The study was approved by the Ethics Research Committee (972.914). Samples of peritumoural adipose tissue were analysed for concentrations of TNF-?, IL-1?, STAT-1, STAT-3, RANTES, IL-1Ra, IP-10, IL-15, MCP-1, IFN-?, GCSF, FADD, and TGF-?. The cytokines and proteins were measured using Multiplex. Correlations between the proteins and cytokines were evaluated.

Results

TNF-?, STAT-1, and FADD, a factor involved in apoptosis, were significantly higher in CC group than in the WSC group. In the peritumoural adipose tissue of the CC group, RANTES showed a significant positive correlation with IL-1Ra and IP-10 and a negative correlation with IFN-?; and GCSF showed significant negative correlations with IL-1Ra, IP-10, IL-15, and MCP-1 and a positive correlation with IFN-?. In the peritumoural adipose tissue of the WSC group, no significant correlations were detected between RANTES, GCSF, IL-3, FADD, and STAT-1 and the cytokines/chemokines analysed.

Conclusions

These results indicated that inflammatory and tumorigenic pathways were altered in peritumoural adipose tissue in CC. Furthermore, inflammatory cytokines were correlated with growth factors in the peritumoural adipose tissue of cachectic patients, suggesting that inflammatory cytokines modulated the proliferative environment closely linked to the tumour.

SUBMITTER: Neto NIP

PROVIDER: S-EPMC6240753 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Peritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients.

Neto Nelson Inácio Pinto NIP Murari Ariene Soares de Pinho ASP Oyama Lila Missae LM Otoch José Pinhata JP Alcântara Paulo Sérgio Martins PSM Tokeshi Flavio F Figuerêdo Raquel Galvão RG Alves Michele Joana MJ Lima Joanna Darck Carola Correia JDCC Matos-Neto Emídio Marques de EM Seelaender Marilia M Oller do Nascimento Claudia Maria CM

Journal of cachexia, sarcopenia and muscle 20181003 6

<h4>Background</h4>Cancer cachexia (CC) is a multifactorial syndrome, often irreversible, that affects patients with cancer influenced, in part, by the inflammatory condition. Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, and growth factors; given the possible crosstalk between the peritumoural adipose tissue and tumour, these may play an important role in cancer biology and carcinogenesis.<h4>Methods</h4>The aim of this study was to evaluate the factors produced by ...[more]

PMID: 30284380

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Dataset Information

Peritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients.

Background

Methods

Results

Conclusions

Publications

Peritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients.

Similar Datasets

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