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Pro-inflammatory cytokines and growth factors in human milk: an exploratory analysis of racial differences to inform breast cancer etiology.

ABSTRACT: BACKGROUND:Analysis of cytokines and growth factors in human milk offers a noninvasive approach for studying the microenvironment of the postpartum breast, which may better reflect tissue levels than testing blood samples. Given that Black women have a higher incidence of early-onset breast cancers than White women, we hypothesized that milk of the former contains higher levels of pro-inflammatory cytokines, adipokines, and growth factors. METHODS:Participants included 130 Black and 162 White women without a history of a breast biopsy who completed a health assessment questionnaire and donated milk for research. Concentrations of 15 analytes in milk were examined using two multiplex and 4 single-analyte electrochemiluminescent sandwich assays to measure pro-inflammatory cytokines, angiogenesis factors, and adipokines. Mixed-effects ordinal logistic regression was used to identify determinants of analyte levels and to compare results by race, with adjustment for confounders. Factor analysis was used to examine covariation among analytes. RESULTS:Thirteen of 15 analytes were detected in ??25% of the human milk specimens. In multivariable models, elevated BMI was significantly associated with increased concentrations of 5 cytokines: IL-1?, bFGF, FASL, EGF, and leptin (all p-trend?

SUBMITTER: Murphy J

PROVIDER: S-EPMC6191357 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Pro-inflammatory cytokines and growth factors in human milk: an exploratory analysis of racial differences to inform breast cancer etiology.

Murphy Jeanne J Pfeiffer Ruth M RM Lynn Brittny C Davis BCD Caballero Ana I AI Browne Eva P EP Punska Elizabeth C EC Yang Hannah P HP Falk Roni T RT Anderton Douglas L DL Gierach Gretchen L GL Arcaro Kathleen F KF Sherman Mark E ME

Breast cancer research and treatment 20180806 1

<h4>Background</h4>Analysis of cytokines and growth factors in human milk offers a noninvasive approach for studying the microenvironment of the postpartum breast, which may better reflect tissue levels than testing blood samples. Given that Black women have a higher incidence of early-onset breast cancers than White women, we hypothesized that milk of the former contains higher levels of pro-inflammatory cytokines, adipokines, and growth factors.<h4>Methods</h4>Participants included 130 Black a ...[more]

PMID: 30083950

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Dataset Information

Pro-inflammatory cytokines and growth factors in human milk: an exploratory analysis of racial differences to inform breast cancer etiology.

Publications

Pro-inflammatory cytokines and growth factors in human milk: an exploratory analysis of racial differences to inform breast cancer etiology.

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