Ontology highlight
ABSTRACT:
SUBMITTER: Grande V
PROVIDER: S-EPMC6240894 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Grande Vincenzo V Shen Chia-An CA Deiana Marco M Dudek Marta M Olesiak-Banska Joanna J Matczyszyn Katarzyna K Würthner Frank F
Chemical science 20180914 44
Fluorescence imaging probes for specific G-quadruplex (G4) conformations are of considerable interest in biomedical research. Herein, we present the synthesis and the binding properties of a new water-soluble near-infrared (NIR) amphiphilic squaraine dye (<b>CAS-C1</b>) which is capable of selective detection of parallel over non-parallel and non G4 topologies. The striking changes in its linear optical response upon binding to parallel G4s give rise to high fluorescence quantum yields (<i>Φ</i> ...[more]