Ontology highlight
ABSTRACT:
SUBMITTER: Shaw JA
PROVIDER: S-EPMC6241844 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Shaw Jacqueline A JA Guttery David S DS Hills Allison A Fernandez-Garcia Daniel D Page Karen K Rosales Brenda M BM Goddard Kate S KS Hastings Robert K RK Luo Jinli J Ogle Olivia O Woodley Laura L Ali Simak S Stebbing Justin J Coombes R Charles RC
Clinical cancer research : an official journal of the American Association for Cancer Research 20160622 1
<h4>Purpose</h4>The purpose of this study was to directly compare mutation profiles in multiple single circulating tumor cells (CTC) and cell-free DNA (cfDNA) isolated from the same blood samples taken from patients with metastatic breast cancer (MBC). We aimed to determine whether cfDNA would reflect the heterogeneity observed in 40 single CTCs.<h4>Experimental design</h4>CTCs were enumerated by CELLSEARCH. CTC count was compared with the quantity of matched cfDNA and serum CA15-3 and alkaline ...[more]