Ontology highlight
ABSTRACT:
SUBMITTER: Hsu JM
PROVIDER: S-EPMC6242346 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Hsu Jung-Mao JM Li Chia-Wei CW Lai Yun-Ju YJ Hung Mien-Chie MC
Cancer research 20181101 22
Posttranslational modifications (PTM) of PD-L1 have emerged as important regulatory mechanisms that modulate immunosuppression in patients with cancer. In exposure to inflammatory cytokines, cancer cells and antigen-presenting cells, such as macrophages and dendritic cells, express PD-L1 to inhibit the activity of effector T cells through PD-1 engagement. Recent studies suggested that glycosylation, phosphorylation, ubiquitination, sumoylation, and acetylation play important roles in the regulat ...[more]