Ontology highlight
ABSTRACT:
SUBMITTER: Zhang JY
PROVIDER: S-EPMC7247431 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhang Jian-Ye JY Yan Yan-Yan YY Li Jia-Jun JJ Adhikari Rameshwar R Fu Li-Wu LW
Frontiers in pharmacology 20200515
Cancer has been a major global health problem due to its high morbidity and mortality. While many chemotherapy agents have been studied and applied in clinical trials or in clinic, their application is limited due to its toxic side effects and poor tolerability. Monoclonal antibodies specific to the PD-1 and PD-L1 immune checkpoints have been approved for the treatment of various tumors. However, the application of PD-1/PD-L1 inhibitors remains suboptimal and thus another strategy comes in to ou ...[more]