Ontology highlight
ABSTRACT:
SUBMITTER: Millan-Zambrano G
PROVIDER: S-EPMC6242705 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20181025 4
In response to genotoxic stress, cells activate a signaling cascade known as the DNA damage checkpoint (DDC) that leads to a temporary cell cycle arrest and activation of DNA repair mechanisms. Because persistent DDC activation compromises cell viability, this process must be tightly regulated. However, despite its importance, the mechanisms regulating DDC recovery are not completely understood. Here, we identify a DNA-damage-regulated histone modification in Saccharomyces cerevisiae, phosphoryl ...[more]