Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC3870678 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Chen Chen C Zhang Liguo L Huang Nai-Jia NJ Huang Bofu B Kornbluth Sally S
Proceedings of the National Academy of Sciences of the United States of America 20131202 51
Ataxia telangiectasia mutant (ATM) is an S/T-Q-directed kinase that is critical for the cellular response to double-stranded breaks (DSBs) in DNA. Following DNA damage, ATM is activated and recruited by the MRN protein complex [meiotic recombination 11 (Mre11)/DNA repair protein Rad50/Nijmegen breakage syndrome 1 proteins] to sites of DNA damage where ATM phosphorylates multiple substrates to trigger cell-cycle arrest. In cancer cells, this regulation may be faulty, and cell division may proceed ...[more]