Ontology highlight
ABSTRACT:
SUBMITTER: Kersten RD
PROVIDER: S-EPMC6243238 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kersten Roland D RD Weng Jing-Ke JK
Proceedings of the National Academy of Sciences of the United States of America 20181029 46
The plant kingdom contains vastly untapped natural product chemistry, which has been traditionally explored through the activity-guided approach. Here, we describe a gene-guided approach to discover and engineer a class of plant ribosomal peptides, the branched cyclic lyciumins. Initially isolated from the Chinese wolfberry <i>Lycium barbarum</i>, lyciumins are protease-inhibiting peptides featuring an N-terminal pyroglutamate and a macrocyclic bond between a tryptophan-indole nitrogen and a gly ...[more]