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HIV-1 drug discovery: targeting folded RNA structures with branched peptides.

ABSTRACT: Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacity to bind in a multivalent fashion, utilizing a large surface area to achieve the necessary affinity and selectivity toward the target RNA.

SUBMITTER: Wynn JE

PROVIDER: S-EPMC4511164 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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HIV-1 drug discovery: targeting folded RNA structures with branched peptides.

Wynn Jessica E JE Santos Webster L WL

Organic & biomolecular chemistry 20150601 21

Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacit ...[more]

PMID: 25958855

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