Ontology highlight
ABSTRACT:
SUBMITTER: Mehta AP
PROVIDER: S-EPMC6243291 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Mehta Angad P AP Supekova Lubica L Chen Jian-Hua JH Pestonjamasp Kersi K Webster Paul P Ko Yeonjin Y Henderson Scott C SC McDermott Gerry G Supek Frantisek F Schultz Peter G PG
Proceedings of the National Academy of Sciences of the United States of America 20181029 46
It has been hypothesized that mitochondria evolved from a bacterial ancestor that initially became established in an archaeal host cell as an endosymbiont. Here we model this first stage of mitochondrial evolution by engineering endosymbiosis between <i>Escherichia coli</i> and <i>Saccharomyces cerevisiae</i> An ADP/ATP translocase-expressing <i>E. coli</i> provided ATP to a respiration-deficient <i>cox2</i> yeast mutant and enabled growth of a yeast-<i>E. coli</i> chimera on a nonfermentable ca ...[more]