Ontology highlight
ABSTRACT:
SUBMITTER: Li XC
PROVIDER: S-EPMC6353624 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Li Xueying C XC Peris David D Hittinger Chris Todd CT Sia Elaine A EA Fay Justin C JC
Science advances 20190130 1
Genetic analysis of phenotypic differences between species is typically limited to interfertile species. Here, we conducted a genome-wide noncomplementation screen to identify genes that contribute to a major difference in thermal growth profile between two reproductively isolated yeast species, <i>Saccharomyces cerevisiae</i> and <i>Saccharomyces uvarum</i>. The screen identified only a single nuclear-encoded gene with a moderate effect on heat tolerance, but, in contrast, revealed a large effe ...[more]